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OJVRTM
Online Journal of
Veterinary Research©
Volume 24(7):
401-406, 2020.
Effect of alhagi camelorum, ziziphus spina christi and levisticum officinale extracts
on blood glucose in normal and diabetic rats.
Mohammadi
Abbass1, Emadi Ladan2,
Barghi Maryam3.
1Physiology Research Center, Kerman University of
Medical Sciences, Kerman and Department of biochemistry, Afzalipour
School of Medicine, Kerman University of Medical Sciences, Kerman,2Department
of Basic Sciences, 3School of Veterinary Medicine, Shahid Baahonar University of
Kerman, Iran.
ABSTRACT
Abbass M, Ladan E, Maryam B., Effect of alhagi camelorum, ziziphus spina christi and levisticum officinale
on blood glucose in normal and diabetic rats, Onl J
Vet Res., 24(7): 401-406, 2020. Glucosidase
inhibitors are currently used to manage metabolic disorders such as diabetes. We
report effect of methanolic extracts of Alhagi camelorum, Ziziphus spinachristi and Levisticum officinal on blood glucose in normal
and diabetic male Wistar rats. Diabetes was induced
with streptozotocin. Groups of 6 diabetic and
non-diabetic rats each were gavaged 2g/kg maltose with
1000mg/kg of each plant extract after 15h food deprivation. Controls were given
2gr/kg maltose with or without 50 mg/kg acarbose. Blood glucose was determined by glucometer 0,
30, 60 and 120 min after treatments. In non-diabetic rats, 2gr/kg maltose increased
(P < 0.05) blood glucose ~23-38% (from ~100 to 160mg/dl) by 30-60 minutes, but
gavaged with 50mg/kg acarbose
did not affect sugar blood. L. officinal extract increased glucose ~33%,
A. Camelorum
~16-33% to 120 minutes and Z. spinachristi ~18-20% to 60min with no diffrenecs with control values. In diabetic rats given
maltose, glucose reached 586.1± 21.2mg/dl by 60min and with acarbose
or L. officionalis and blood glucose rose ~20%. However, in
rats given A camelorum or Z.
spina Christi blood glucose did not increase significantly suggesting these extracts may induce anti-diabetic effects
in rats.
Keywords: Diabetes mellitus, Alpha glucosidase,
Alhagiacamelorum and Ziziphusspina
and levisticum officinal.
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