©1994-2018. All Rights Reserved. Online Journal of
Veterinary Research. You may not store these pages in any form except for your
own personal use. All other usage or distribution is illegal under
international copyright treaties. Permission to use any of these pages in any
other way besides the before mentioned must be gained in writing from the
publisher. This article is exclusively copyrighted in its entirety to OJVR
publications. This article may be copied once but may not be, reproduced or
re-transmitted without the express permission of the editor.
OJVRTM
Online Journal of Veterinary Research©
Volume 13 (1):130-137, 2009. Editors note: Extensive Redaction 2017.
Dose
dependent acepromazine-xylazine effects on
intraocular pressure, pupil size and heart rate, in clinically normal dogs
Sarchahi AA, Vesal N, Gholipour MA.
Department
of Veterinary Clinical Studies,School
of
Sarchahi AA, Vesal N, Gholipour MA. Dose dependent acepromazine-xylazine combination effects on intraocular pressure, pupil size and heart rate, in clinically normal dogs, Onl J Vet Res 13(1): 130-137, 2009. Dose dependent effects of intramuscular acepromazine-xylazine combinations with atropine on intraocular pressure (IOP), pupil size and heart rate were evaluated in 24 dogs. Groups of 12 dogs each were given 0.05 mg/kg acepromazine maleate (LA) with 0.5 mg/kg xylazine hydrochloride (HX), 0.03 mg/kg LA with 0.8 mg/kg HX, 0.08 mg/kg HA with 0.3 mg/kg HX, or 0.05 mg/kg HA with 0.5 mg/kg HX and 0.04 mg/kg atropine. Two treatments were tested in each dog with at least 8 days between treatments. Drugs were mixed in a syringe prior to administration and injected intramuscularly into the thigh muscle. Following drug administration, dogs were left undisturbed in their cage for 15-20 minutes. IOP of left eye 16.4 ± 2.6 was lower than that the right eye 17.7 ± 2.7 (P < 0.018) but differences in pupil size did not occur before drug injections. In those given LA there was no difference in IOP but in those given LA-HX, IOP declined in both eyes. In dogs injected LA with HX or with atropine IOP declined in both eyes but only differences in right eyes were statistically significant (P < 0.05). We found no difference in IOP between eyes in treated dogs. Heart rate in dogs given LA or LA and HX declined (P < 0.00001). Results showed a decreasing effect on IOP in both right and left eyes following sedation with various doses of acepromazine-xylazine combinations with or without atropine, although these changes were within normal ranges.
Key
words: acepromazine, atropine, dog, intraocular
pressure, pupil size, heart rate, xylazine
FULL-TEXT
(SUBSCRIPTION OR PURCHASE TITLE $25USD)