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OJVRTM
Online Journal of Veterinary Research©
Volume 18(2):176-, 2014. Redacted 2017.
Effect of ionophore salinomycin on antibiotic resistance in Escherichia coli
isolated from dogs.
Sohrabi Z1,
Hosseinzadeh S1, Rajaian
H2, Derakhshandeh A, MazaheriNezhadFard R4.
1Departments
of Food Hygiene, 2Basic Sciences, 3Pathobiology, School of
Veterinary Medicine, Shiraz University, 4Rastegar Central Laboratory, Faculty of
Veterinary Medicine, University of Tehran, Iran.
ABSTRACT
Sohrabi Z, Hosseinzadeh S, Rajaian H, Derakhshandeh A, MazaheriNezhadFard R., Effect of ionophore
salinomycin on antibiotic resistance in Escherichia
coli isolated from dogs, Onl J Vet Res., 18(2):176-187, 2014. Epidemic antimicrobial
resistance in various bacteria has been considered as a major threat to human
health. In recent decades, tetracycline resistance has increased in Escherichia
coli, mostly encoded by tetA gene. This is
mainly due to extensive use of this antibiotic or the mobility of resistance
genetic elements amongst the bacterial population. Studies have reported the
effect of ionophores on the transfer of these
elements and, therefore, the resistance profile of the bacteria. An in vivo
canine model was developed to assess tetA
encoded tetracycline resistance in E. coli in the presence of an ionophore, salinomycin. Results
showed similar resistance rates in experimental groups treated with salinomycin and tetracycline and those receiving
tetracycline alone. Results were further confirmed by a PCR assay. In summary,
no effect of salinomycin was observed on tetracycline
resistance pattern of the commensal E. coli isolated from dogs.
Keywords:
Antimicrobial
resistance, Tetracycline, Ionophore, salinomycin
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