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OJVRTM

Online Journal of Veterinary Research©

Volume 20(6):389-395, 2016.


Electrocardiographic changes in Holstein calves after dexamethasone and isoflupredone administration.

 

Aliasghar Chalmeh*, Seyyed Mohammad Mehdi Heidari, Mohammad Reza Zarei, Mehrdad Pourjafar, Saeed Nazifi

 

 

School of Veterinary Medicine, Shiraz University, Shiraz, Iran

 

ABSTRACT

 

Chalmeh A, Mehdi Heidari SM, Zarei MR, Pourjafar M, Nazifi S., Electrocardiographic changes in Holstein calves after dexamethasone and isoflupredone administration, Onl J Vet Res.,  20(6):389-395, 2016. Glucocorticoids can cause serum electrolyte imbalance affecting membrane action potentials. Two groups of 5 Holstein 6-10 month old calves were given 1mg/kg intramuscular dexamethasone sodium phosphate or 1mg/kg isoflupredone acetate on 2 consecutive days. Blood samples were taken at day 0 (1st administration), 1 (2nd  administration), 2, 3, 5 and 7 for determination of serum Na+, K+, Cl-, Ca+, Mg+ and P+. Electrocardiograms were recorded from calves on same day of blood samplings. Duration of S and T waves, amplitude of S and R waves and P-R, R-R, S-T and Q-T intervals increased (P<0.05) after dexamethasone and isoflupredone administration. R-amplitude decreased to base line at 5th and 7th days in both groups. Serum K+, Cl-, Ca+ and P+ concentrations declined (P<0.05) after isoflupredone administration and were lower than in cows given dexamethasone. Findings suggest that changes in serum electrolytes may have been due to isoflupredone and dexamethasone affecting ECG. The result must be interpreted with caution as they were not compared with saline controls. 

 

Keywords: Glucocorticoids, Electrolyte imbalances, Cardiac action potential, Electrocardiography, Holstein calves.


 

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