MAIN


©1996-2009 All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


OJBTM

Online Journal of Bioinformatics©

 

 Volume 8 (2) : 154-164, 2007


The 3D structure of the Japanese Encephalitis helicase, using homology

based molecular modelling techniques

 

Vlachakis D, Brancale A

 

Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, United Kingdom


ABSTRACT

 

Vlachakis D, Brancale A., The 3D structure of the Japanese Encephalitis helicase, using homology based molecular modelling technique, Online J Bioinformatics 8 (2) 154-164, 2007. The helicase plays a key role in the life cycle of viruses of the Flaviviridae family.  Japanese encephalitis virus is a member of this family and constitutes an important human pathogen (1). In this work, towards a structure-based design of novel anti-japanese encephalitis agents, a 3D-model of the japanese encephalitis helicase virus was produced using homology modelling techniques and the known 3D-structure of the yellow fever helicase of the Flaviviridae family as template.

 

Keywords: Homology modelling; Molecular Dynamics; Helicase; Japanese Encephalitis Virus; Flaviviridae.


MAIN

 

FULL-TEXT (SUBSCRIPTION)