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OJVRTM
Online
Journal of Veterinary Research©
Volume 12 (1) :46-49, 2008. Editors note: Extensively Redacted 2018.
Effects of vitamin C on ketamine-diazepam anesthesia
in dogs
Marjani M1, Selk Ghaffari M1, Bahonar AR2,
Yazdanpanah Abdolmaleki A1.
1Department
of Clinical sciences, Faculty of Veterinary Medicine, Islamic Azad
University-Karaj Branch. Karaj- Iran. 2Department
of Epidemiology, Faculty of Veterinary Medicine, University of Tehran. Tehran-
Iran.
ABSTRACT
Marjani M, Selk Ghaffari M, Bahonar AR, Yazdanpanah
Abdolmaleki A Effects of vitamin C on ketamine-diazepam anesthesia in dogs, Onl J Vet Res., 12 (1):46-49, 2008. The effect of
vitamin C on anesthesia induced by ketamine-diazepam in dogs is reported. Heart
and respiratory rates, duration of anesthesia, body temperature, blood glucose,
and calcium were evaluated before and after induction. Groups of five dogs each
were given 4ml saline (controls), intravenous ketamine-diazepam or premedicated with 100 mg or 500 mg vitamin C 30 minutes
before induction. Compared with dogs given only ketamine-diazepam we found a
significant increase in body temperature and blood glucose in dogs given
vitamin C. Mean ± SD duration of anesthesia was significantly longer (P < 0.02)
in dogs injected ketamine-diazepam (41.8 ± 2.8 minutes) compared with those
given 100mg (22.6 ± 2.5 minutes) or 500mg (23.2 ± 2.03 minutes), vitamin C. Our
findings suggest that premedication with vitamin C may be of use in dogs with
pre-surgical hypothermia, hypoglycemia, or in those in risk with prolonged
anesthesia.
Key words: vitamin C, ketamine, diazepam, anesthesia, dog.
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