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OJVRTM

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume  29 (9): 575-582, 2025.


Effects of ketamine, xylazine, tiletamine and zolazepam on anesthesia, heart-respiration rates and blood pressure in monkeys over 24h.

 

Cheah PS, Low CK, Mohidin N, Bariah MA, Maung M, Azian AL.

 

Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.

 

ABSTRACT

 

Cheah PS, Low CK,Mohidin N, Bariah MA, Maung M, Azian AL., Effects of ketamine, xylazine, tiletamine and zolazepam on anesthesia, heart-respiration rates and blood pressure in monkeys over 24h, Onl J Vet Res., 29 (9) : 575-582, 2025. We report effects of ketamine, xylazine (KT/XY), tiletamine and zolazepam (KT/XZ), on anesthesia, heart-respiration rates and blood pressure in 8 cynomolgus monkeys over 24h. Monkeys were induced by 0.1ml/kg intramuscular KT/XY and anesthetized with 0.2mg/kg intravenous KX/TZ. Subjects were monitored by jaw tone, palpebral and pedal withdrawal reflexes and rigidity of muscles every hour and anesthesia maintained by intravenous 0.1mg/kg KX/TZ. Ketamine produced poor myo-relaxation whereas KX/TZ induced smooth muscle relaxation in all by 2min. Nine extra doses of KX/TZ maintained anesthesia for 24h. Anesthesia with induction doses was 136±25min in females and 173±26min in males. We find that tiletamine-zolazepam doses may adjunct ketamine-xylazine to prolong anesthesia in monkeys.

 

Keywords  ketamine-xylazine, tiletamine-zolazepam, cynomolgus monkey, anesthesia