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OJVRTM
Online Journal of Veterinary
Research©
Volume 17(7):360-369, 2013. Slightly Redacted 2017.
Inhibitory
effects of walnut consumption on amygdala kindling model of epilepsy in male Wistar rats
Shaahin Harandi (MSc)1,2,
Mehdi Abbasnejad (PhD)1, Javad Mirnajafi-Zadeh (PhD)3,
Saeed Esmaeili-Mahani (PhD)1, Khadije Esmaeilpour (MSc)2,
Majid Asadi-Shekaari
(PhD)2, Ali Mostafavi
(PhD)4, Vahid Sheibani
(PhD)2*
1Department
of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, 2Neuroscience Research Center,
Kerman University of Medical Sciences, 3Department of Physiology,
Faculty of Medical Sciences, Tarbiat Modares University, Tehran, 4Chemistry
Department, Shahid Bahonar
University of Kerman, Kerman, Iran. Correspondence: Vahid
Sheibani, PhD, V_sheibani@kmu.ac.ir,
Vsheibani2@yahoo.com
ABSTRACT
Harandi S, Abbasnejad M, Mirnajafi-Zadeh J, Esmaeili-Mahani S, Esmaeilpour K,
Asadi-Shekaari M, Mostafavi
A, Sheibani V., Inhibitory effects of walnut
consumption on amygdala kindling model of epilepsy in male Wistar
rats, Onl J Vet Res., 17(7):360-369,
2013. Bipolar stimulation and monopolar recording electrodes were planted stereotaxically in the right basolateral amygdala of 4
groups of 6 male Wistar rats each. Groups were given
a daily IP injection of saline for 2 weeks, fed 1.2g walnuts daily for 2
months, or injected daily IP 4.5ng melatonin for 2 weeks. Controls were
untreated normal rats. After treatments all rats were subjected to kindling
stimulation. Duration of after discharges, daily seizure stages, walnut
melatonin concentration and serum melatonin were then determined in all rats.
In groups given walnut kernels or injected with melatonin (to induce the same
concentration as the ingestion of 1.2g walnuts), there was significant increase
in serum melatonin. In rats ingesting
walnuts there was a significant inhibitory effect on epileptogenesis
compared with control or saline groups which may possibly be attributed to the
high melatonin content of these nuts.
Keywords:
Amygdala; Epilepsy; Kindling; Melatonin; Seizure; Walnut.
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