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OJVRTM
Online Journal of Veterinary Research ©
Volume 15 (3): 190-199, 2011. Redacted 2018.
Detection of single nucleotide polymorphism in TATA box of Lactoferrin and its association with uterine infections in
cows
R. Valadan1, A. Mirzaei1,
H. Sharifiyazdi1*, A. Rowshan Ghasrodashti2,
H. Safari1
1Department
of Clinical Science, School of Veterinary Medicine, Shiraz University, Shiraz
71345, Iran; 2Islamic Azad University, Kazerun
Branch, Kazerun, Iran
ABSTRACT
Valadan R, Mirzaei A, Sharifiyazdi H, Ghasrodashti RA, Safari H., Detection of single nucleotide
polymorphism in TATA box of Lactoferrin gene and its
association with uterine infections in cows. Onl J
Vet Res., 15 (3): 190-199, 2011. The relationship between an A/C single nucleotide
polymorphism at position -28 within TATA box region of lactoferrin
promoter and postpartum uterine infection and reproductive performances in
Holstein dairy cows was evaluated. Created Restriction Site PCR was used to
screen two groups of cows with and without a history of uterine infection.
Results showed that CC genotype had a significant association with postpartum
uterine infection and tended to require a higher service per conception, and
longer calving period, compared with AC and CC genotypes. The findings
suggested that the TATA box mutation may contribute to the expression of the lactoferrin gene, which in turn, might be a useful marker
of resistance to postpartum infection in dairy cattle.
Keywords:
Uterine infection; Lactoferrin; TATA box;
Polymorphism; Dairy cow.