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OJVRTM
Online Journal of Veterinary Research©
Volume 26 (5): 344-351, 2022.
Evolution of lateral gene transfer in pathogenic
microbial Biofilm
Nidhi Mathur, Ravneet Chug
Amity Institute of Biotechnology, Amity
University, Rajasthan.
ABSTRACT
Mathur N, Chug R., Evolution of lateral gene transfer in
pathogenic microbial biofilm, Onl J Vet Res., 26 (5): 344-351, 2022. Biofilms are polymers secreted by microbes which form densely colonies
to grow on living or inert surfaces. About 60-80% human infections involve
biofilm microbes. We extracted 16s rRNA gene
sequences of 17 human pathogenic biofilm bacteria from GenBank.
For quorum sensing, bacteria to sustain environment with autoinducer
and transporter proteins we retrieved sequences from Swiss-Prot
[19] finding only 12 bacteria producing these proteins. Sequences were aligned for phylogenetic
analysis and tree with Phylip-Protml. Phylogenetic
analysis revealed Legionella spp, Staphylococcus spp and Alteromonas spp common
evolutionary tree nodes with Legionella pneumophila being
its oldest ancestor. Lineage associated with adhesion, toxicogenesis and autoinduction
proteins in 12 of 17 bacteria evolved earliest in Salmonella spp and hemolytic toxin in Salmonella spp. Lateral gene transfer was
deduced by the patchy scattered phylogenetic tree.
Key-words: Biofilms, pathogenesis, phylogenetic analysis,
toxicogenesis,16s rRNA.
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