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OJVRTM
Online
Journal of Veterinary Research©
Volume 24 (1):28-37, 2020.
Effect of ..Lavandula angustifolia on cisplatin cytotoxicity in MCF-7
breast cancer cell line.
Sedigh-Ardekani
Mozhgan1, Fazeli Mehdi2*, Masoudian Maliheh3,
Ghahramani Seno Mohammad Mahdi4*
1Department(s)
of Biotechnology, 2Basic Sciences, 3Central Lab. School
of Veterinary Medicine, Shiraz University, Shiraz, 4Division of
Biotechnology, Department of Pathobiology and Department of Basic Sciences,
School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
ABSTRACT
Mozhgan SA, Mehdi F, Maliheh
M, Mohammad Mahdi GS., Effect of Lavandula angustifolia on cisplatin cytotoxicity in MCF-7 breast
cancer cell line, Onl J Vet Res., 24 (1):28-37,
2020. Chemotherapy to manage breast cancer may
affect normal and cancer cells as well as inducing resistance requiring lower
initial dosages. Herbal extracts per se are
not used to treat cancer but as supplements may reduce adverse effects and drug
resistance associated with chemotherapy. We report effect of lavender flowers Lavandula angustifolia
on cytotoxicity of cisplatin on MCF-7 breast cancer cell line. Extracts characterized
by gas chromatography-mass spectrometry (GC/MS) identified linalool, Camphor, 1,8-cineole, lavandulyl acetate, borneol, linalyl acetate and
β-bisabolene. MTT assay was used to determine
the cytotoxicity index (IC50) of the lavender’s hydro methanolic
extract on MCF-7 and MCF10A normal breast cell line for 24 or 48 hrs. The cells
were then co-treated with the extract and cisplatin at various concentrations for
24 or 48 hrs. Results suggested that the extract per se was slightly toxic to normal breast cells (MCF-10A) but given
with cisplatin inhibited MCF-7 cancer cells ~60% at 24h or 48h (P < 0.05).
Keywords: Lavandula angustifolia, breast cancer, MCF-7, MCF-10A, cisplatin,
herbal medicine. Raw data provided.
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