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OJBTM

Online Journal of Bioinformatics©

Volume 18(2):78-85, 2017.


Pathway analysis of sequences in Mycobacterium Tuberculosis and Leprae

 

Lakshmi Pillai and  Usha Chouhan.

 

Department of Computational and Integrated Science MANIT, Bhopal  

 

ABSTRACT

 

Pillai L, Chouhan U., Pathway analysis of sequences in Mycobacterium Tuberculosis and Leprae. Onl J Bioinform., 18(2):78-85, 2017. We classify Mycobacterium Tuberculosis and Mycobacterium Leprae on carbon metabolism pathway from NCBI and Swissprot/Uniprot databank Expasy server and Biocyc.org. Comparative pathway analysis resulted in 182 pathways of M. leprae and 209 in M. tuberculosis, where 28 amino acid pathways were in M. leprae and 38 in Mycobacterium tuberculosis.  We found that M. leprae metabolizes glucose, but other carbon sources are not metabolized for energy. There are pseudogenes in M. leprae that correspond to M. tuberculosis for proteins that enable bacteria to breakdown other carbon sources such as acetate and galactose. Genes responsible for H37Rv to grow in macrophage like trp D, pro C and met C are possible drug target genes. The carbon metabolic pathway analysis suggests commonality between M. tuberculosis and leprae pathways for identification of drug targets.

 

 

Keywords: Mycobacterium Tuberculosis (M.TB), M. Lepare, Pathway analysis, Fibrosis, Granuloma, Axenically.


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