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OJVRTM
Online Journal of Veterinary
Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 28(3): 167-173, 2024.
Phylogenetic Mycobacterium
leprae genome drug targets
Saxena A Varadwaj PK,
Singh S Lahiri T.
Indian Institute of Information
Technology, Allahabad, India
Deoghat Jhalwa Campus, RajRooppur
Road, alllahabad
– 211011(U.P.) ( www.iiita.ac.in
), *Corresponding author: pritish@iiita.ac.in
ABSTRACT
Varadwaj SA, Lahiri SS., Phylogenetic
Mycobacterium leprae genome drug targets, Onl J Vet Res., (3): 167-173, 2024. Reductive evolution
filters out pathogen gene set by gene losses to be able to target drug like
molecules. Proteins predicted from genome sequence of M. leprae with 2712 FASTA sequences were
used to identify horizontally transferred genes by similarity by BLASTP eukaryotes
and bacteria in GENBANK wherein proteins scoring 10 E or more were selected.
Mycobacteria sequences were removed and absence of bacterial orthologs confirmed by similarity search. Bacterial
sequences identified by PSI-BLASTA were aligned using CLUSTALW and subject to
phylogenetic analysis, using the neighbor joining and protein parsimony methods
of the PHYLIP package. Non-congruent phylogeny with bootstrapping
support => 70 %, were classified as horizontal gene transfer. We identified prolyle tRNA synthetase
and uridine phosphorylase in Mycobacterium
leprae.
KEY-WORDS: Horizontal gene transfer, Computational evolutionary analysis.
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