©2026-2038 All Rights Reserved. Online Journal of Veterinary Research.  You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to onlinejournals@gmail.com publications.. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.  

      

OJVRTM

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 30 (5): 286-292, 2026

Levothyroxine serum biochemistry and effect on liver in Ross broilers.

 

Emadi Ladan DVM PhD, Kheirandish Reza DVM PhD, Amiri Narjes DVM.

 

Basic Science and Pathobiology Departments, Shahid Bahonar University, Kerman, Iran.

 

ABSTRACT

 

Ladan E, Reza K, Narjes A., Levothyroxine serum biochemistry and effect on liver in Ross broilers. Onl J Vet Res, 30 (5): 286-292, 2026. Effect of oral levothyroxine on serum biochemistry and liver histology was evaluated in Ross broiler chicks. Two groups of 12 chicks each were given daily oral levothyroxine sodium 250 or 500 μg/Kg at 14 days age for 25 days to induce hyperthyroidism. Compared with non-treated controls (n=12), in those given 250 or 500 μg/kg, tri-iodothyronine declined (P < 0.001) ~50%, thyroxine increased 76- 82%, alanine transaminase 27-51% and aspartame 23-24%, reduced triclycerides 27-43%, and cholesterol 41-43%.  By microscopy, in birds given levothyroxine, we observed hepatic cytoplasmic basophilia, euchromatin nuclei, lymphopoiesis in liver and vascular smooth muscle hypertrophy more evident in those given 500ug/kg levothyroxine.  We find that >250ug/kg levothyroxin may induce hepatotoxicity in chicks.

 

Key Words: Hyperthyroidism, Hepatic function, Chicks.

MAIN

 

FULL-TEXT (SUBSCRIBE OR PURCHASE TITLE)