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Online Journal of Veterinary Research©

 

Volume 26 (4): 313-322, 2022.

Intravenous lidocaine toxicity in chickens (Gallus domesticus)

 

Hadi Imani1 DVM, Nasser Vesal1 DVM MVSC, Soliman Mohammadi-Samani2, Pharm D PhD.

 

1Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Shiraz University, 2Pharmaceutical Science Research Center, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran

 

ABSTRACT

 

Imani H, Vesa N, Mohammadi-Samani S., Intravenous lidocaine toxicity in chickens (Gallus domesticus), Onl J Vet Res., 26 (4): 313-322, 2022. We report toxic lidocaine doses and serum levels that result in clinical toxicity in chickens. Eight healthy, female, 55-week-old broiler (Lohman breed) chickens weighing 1.45 ± 0.17 kg (mean ± SD) were used. A loading dose of 2% lidocaine (4 mg/kg) was administered IV, followed by a constant-rate infusion at a dose of 8 mg/kg/min using a syringe pump. Times to onset of convulsion and/or respiratory arrest were recorded and the total toxic dose of lidocaine was determined. Blood sample was withdrawn for lidocaine analysis at the onset of the major signs of intoxication (convulsion or respiratory arrest). The total toxic dose of lidocaine required to produce systemic toxicity and corresponding serum lidocaine concentration were 28.96 ± 6.21 mg/kg and 38.5 ± 10.4 µg/mL, respectively. Based on the results of this study, greater doses of lidocaine are needed to produce toxic manifestations in chickens compared with mammals.

 

Key words: Lidocaine, Infusion, Toxicity, Chicken.

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