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OJVRTM
Online Journal
of Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 30 (8): 489-501, 2026.
Effect of alpha lipoic acid on testicular toxicity induced by
pesticides in Albino rats.
Azza M. Gawish
Department of Animal, Faculty of Science, Cairo
University, Giza, Egypt
ABSTRACT
Gawish AM.,
Effect of alpha lipoic acid on testicular toxicity induced by pesticides, Onl J Vet Res., 30 (8): 489-501, 2026. The Effect of alpha-lipoic acid
(ALA), on biochemical and tissues in 4 groups of 5 male albino rats each were
treated 2mg/Kg 1/60LD50 chloropyrifos, 2.5 mg/kg
1/200 LD50 fenitrothion
200 mg/rat ALA being pesticides with or without ALA. Controls were not treated.
Compared with controls, pesticides enhanced (P < 0.05) malondialdehyde
(MDA) 46%. Concerning testosterone, pesticide reduced (P < 0.05) it by
32%. However, when alpha lipoic acid was
given with pesticide it only declined 9% (P < 0.05). Samples were taken at
14 and 28 days. By microscopy, in rats given pesticides, in testes we observed
mild focal testicular necrosis, hemorrhage and hypo-spermatogensis
and atrophy. By masson-trichrome
stain we found fibrosis and by immune TUNEL chemistry increased apoptosis
between germ cells. There was depletion of acid phosphatase for biosynthesis of
testosterone. Alpha lipoic acid inhibited damage to seminiferous tubules, spermatogenic germ and interstitial cells and fibrosis.
Keywords: Pesticides – Reproduction - Apaptosis - Fibrosis – Antioxidants.
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