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OJVRTM
Online Journal of
Veterinary Research©
Volume 7:99-105, 2003. Redacted 2018.
Effect of sub-acute
doses of maduramycin in broiler chicks
Arun KHS1, Manjunath HS*, Reddy KS,
Reddy R, Kalakumar B.
Department of Pharmacology and
Toxicology, College of Veterinary Science, ANGRAU, Rajendranagar,
Hyderabad, India. @ Dept of LPM. * Biochemist, Biocon India Ltd., Bangalore,
India. 1 corresponding author: Address for correspondence: Dr. Arun Kumar HS, Cardiovascular and Receptorology
lab, Dept of Pharmacology & Toxicology, National
Institute of pharmaceutical Education and Research (NIPER), Phase X, Mohali,
Punjab:16062, India, Phone: 0172-214682 ext 2041.
E-mail: hsarunk@yahoo.com. Note: The study is part of the MVSc
(Pharmacology & Toxicology) thesis submitted to Dept
of Pharmacology & Toxicology, ANGARU, Hyderabad, by the first author.
ABSTRACT
Arun KHS1, Manjunath
HS*, Reddy KS, Reddy R, Kalakumar B. Effect of
sub-acute doses of Maduramycin in Broiler Chicks. Onl J Vet Res., 7: 99-105, 2003. Effects of
8-ppm oral maduramycin (mixed with feed) on broiler
chicks was evaluated. Toxic signs included in-coordination, lethargy, leg
weakness, diarrhea, reduced feed intake and weight loss. Sternal recumbency with neck, wings and hind limbs outstretched
were characteristic and prominent by the 4th week. Extensive pathological
lesions were observed in skeletal muscle, heart, lungs, kidney, liver,
intestines and bursa. Serum alanine aminotransferase, aspartate
aminotransferase, alkaline phosphatase and lactase dehydrogenase activity and
urea, creatinine and cholesterol levels increased whereas total protein,
albumin and globulin levels decreased. Hematological studies revealed severe macrocytic
hypochromic anemia. There were no significant changes in the parameters
measured in control 5-ppm maduramycin fed birds. The
results suggest extensive changes in biochemical profiles and vascular
integrity due to maduramycin given at 8ppm. The results
show that maduramycin should be mixed with feed
correctly to ensure its appropriate levels.
KEY-WORDS: Maduramycin,
biochemical parameters, broiler chicks and subacute toxicity.