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OJVRTM
Online Journal of Veterinary Research©
Established 1994
Satarudra Prakash Singh (PhD), Feroz
Khan (PhD) and BN Mishra (PhD)
1,2,3 Department of Biotechnology,
Institute of Engineering & Technology, U. P. Technical University, Sitapur Road, Lucknow-226021 (U.P.) INDIA.
Singh SP, Khan F, Mishra BN.,
Genome-wide prediction for malaria vaccine epitopes in P. falciparum, Onl J Vet Res., 25(4):291-300, 2021. Effective malarial
vaccine is hampered by life cycle of Plasmodium
falciparum, which expresses complex antigens during development. Plasmodium
does not grow well in cell culture so that computation could be used to develop
an In silico vaccine. P. falciparum genome (23 Mb) encodes >5300 proteins, potential
targets for immune response. Current subunit vaccines target a single or few antigens
and thus cannot elicit wide response. Immune responses to Plasmodium are dispersed on a relatively large number of parasite
antigens and an effective vaccine should target immunogenic regions or epitopes
of the Plasmodium genome/proteome
that are highly conserved. We report PROPED prediction of genome/proteome
promiscuous helper T and cytotoxic T lymphocyte epitopes in P. falciparum for malaria vaccine.
Key-words: Malaria,
Plasmodium falciparum, genomics,
proteomics, subunit vaccine, T-cell, epitope, bioinformatics.