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OJVRTM
Online Journal of
Veterinary Research©
Volume 20(1):7-20, 2016.
Associations
between serum leptin, adiponectin, insulin, C-reactive protein
and serum
long-chain linolenic acids (Omega 3) in Mastiff dogs
Amir Hossein Asgari Safdar
Young Researchers and Elite Club, Islamic Baft Branch Azad University, Baft,
Iran
ABSTRACT
Asgari Safdar AH., Associations between serum
leptin, adiponectin, insulin, C-reactive protein and serum long-chain linolenic
acids (Omega 3) in Mastiff dogs, Onl J Vet Res., 20(1):7-20, 2016. Obesity has been associated with an increased inflammatory
response and insulin resistance due to adipose tissue–derived adipokines and increases in C-reactive protein (CRP). Dogs
appear to be similar to other species with the exception of adiponectin, which
might not be affected by obesity status. Serum long-chain polyunsaturated fatty
acid concentrations have been positively and negatively associated with serum adipokines. The aim of the study was to examine the
relationship between leptin, CRP, adiponectin, and insulin to body condition
score (BCS) and to the long-chain omega-3 fatty acids in serum lipoproteins,
including alpha-linolenic acid, eicosapentaenoic acid
(EPA), docosapentanenoic acid (DPA), and
docosahexaenoic acid (DHA) as a reflection of dietary omega-3 status in the
Persian Mastiff. Seventy-seven Persian Mastiff were
evaluated for BCS, percent fasting serum lipoprotein fatty acid concentrations,
as well as serum leptin, adiponectin, insulin, and CRP. A multivariable general
linear regression model was constructed to examine the association between the
dependent variables leptin, CRP, adiponectin, and insulin and the predictor
variables of BCS, age, and sex, as well as concentrations of alpha-linolenic
acid, EPA, DHA, and DPA. Adiponectin concentration was positively associated
with age (P<0.0008), EPA (P=0.027) and negatively associated
with DHA (P=0.008). Leptin concentration was positively associated with
an increased DHA (P=0.009), BCS (P<0.0001), age (P=0.02),
and decreased DPA (P=0.06). Insulin concentration was only associated
with BCS (P<0.0001), and no meaningful associations were found for
CRP. Longer chain omega-3 fatty acids may play a role in regulating adiponectin
concentrations in dogs. However, because insulin concentrations were associated
only with BCSs, further examination of the role of adiponectin in canine
obesity is warranted. EPA and DPA may reduce the overall inflammatory state in
dogs as these omega-3 fatty acids reflect increased adiponectin (increased EPA
and decreased DHA) and decreased leptin (decreased DHA and increased DPA).
Keywords: obesity, dog, adiponectin, omega-3 fatty acid, insulin, leptin.
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