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OJVRTM

 Online Journal of Veterinary Research©

 

Volume 18(4): 316-330, 2014. Redacted 2017.


Effects of a 28 day oral meloxicam or carprofen treatment in dogs.

 

Neiva de Mello Portugal, Manuella DVM, MVSc1; Erthal, Elizabeth2; Fernandes Alcântara, Corinne DVM3:  Knopf, Thaís3; Benevenho,

Ana Carolina DVM, MVSc4; Miara, Liv Cristina DVM, MVSC5;Villanova Junior, José Ademar DVM, PhD6; Michelotto Junior, Pedro 6;

Turra Pimpão, Cláudia6.

 

1,2Faculties of Veterinary Science, Pontifícia Universidade Católica do Paraná (PUCPR);  3,4,5University of São Paulo and 6Animal Science Course, PUCPR, Br 376, km 14, Costeira, São José dos Pinhais, Paraná, Brazil.

 

ABSTRACT

 

Neiva de Mello Portugal M, Erthal E, Fernandes Alcantara C, Knopf T, Benevenho AC,  Miara LC, Villanova Junior JA, Michelotto Junior P, Turra Pimpão C., Effects of a 28 day oral meloxicam or carprofen treatment in dogs. Onl J Vet Res., 18(4): 316-330, 2014. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in veterinary medicine for treatment of chronic and acute pain but its indiscriminate use has been linked to Gastric Erosive-ulcerative Disease. The effect of oral carprofen and meloxicam given for 28 consecutive days on clinical, gastroscopical and histopathogical findings in dogs is reported. Groups of 6 dogs each were given oral 4.4mg carprofen/kg or meloxicam 0.1mg/kg. A group of 4 controls were not treated. All groups underwent the same protocol. Liver function, urinalysis and complete blood count did not change between groups or before and after treatments and remained within normal limits. However, dogs given carprofen had isolated episodes of vomiting and diarrhea during treatment and those treated with meloxicam suffered diarrhea, melena and hematochezia after the 14th day of treatment. All dogs showed mild to moderate macroscopic and microscopic gastric mucosal variations without any significant difference between groups. The findings suggest it is possible to orally administer carprofen to dog for 28 consecutive days without undue effects. Treatments with meloxicam may have induced clinical signs of gastropathy after the 10th day of treatment.

 

Key words: Endoscopy; Collateral effects; Gastric Erosive-Ulcerative Disease.

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