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OJVRTM

Online Journal of Veterinary Research©

Volume 20(3):199-204, 2016.

 

 Effect of Artemisia sieberi or Terbinafine 1% on Trichophyton mentagrophytes infection in Guinea pigs

 

Seyed Morteza Razzaghi Manesh1, Siamak Mashhady Rafie1, Farnoosh Arfaee1, Mansour Bayat2

 

1Small Animal Medicine, 2Mycology, Science and Research branch, Islamic Azad University, Tehran, Iran.

 

ABSTRACT

 

Razzaghi Manesh SM, Rafie SM, Arfaee F, Bayat M., Effect of Artemisia sieberi and Terbinafine 1% on Trichophyton mentagrophytes infection in Guinea pigs, Onl J Vet Res., 20(3):199-204, 2016. Effects of Artemisia sieberi essence or Terbinafine 1% cream on experimental dermatophytosis caused by Trichophyton mentagrophytes in guinea pigs are described. Standard protocol M38-A (CLSI) was used to determine minimum inhibitory concentration (MIC) of 1.1µg/mL for Artemisia sieberi essence. Groups of 6 guinea pigs each were treated after day 5 of infection every 12 hours with Terbinafine 1% cream or A. sieberi essence. Controls were non-treated infected and non-infected saline guinea pigs. Animals were evaluated clinically and by laboratory tests recorded in SPSS. By 6 weeks, Artemisia sieberi had reduced (p<0.05) fungal infections 100% and Terbinafine ~67%. Results suggested that Artemisia sieberi essence may improve treatment of Trichophyton mentagrophytes dermatophytosis.

 

Keywords: guinea pig, dermatophytosis, Artemisia sieberi , Terbinafine cream, Trichophyton mentagrophytes.

 

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