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OJVRTM
Online Journal of Veterinary
Research©
Volume 22 (7):596-601, 2018.
Effect of
gentamycin and calcium EDTA on mesenteric lymph nodes in rabbits
following oral Salmonella typhimurium infection.
Ahmed Sami Jarad1,
Zaid Yaseen Ibrahim1, Rafid,
K. Ali1, Mustafa Salah Hasan1, Maher Saber Owain2,
Mohammed Ali Hussein1
1Department(s)
of Internal and Preventive Veterinary Medicine, College(s) of Veterinary
Medicine, University of Fallujah, 2University of Tikrit, Iraq.
ABSTRACT
Jarad AS, Ibrahim ZY, Ali RK, Hasan MS, Owain MS,
Hussein MA., Effect of gentamycin and calcium EDTA on mesenteric lymph node of
rabbits following Salmonella typhimurium infection, Onl
J Vet Res., 22 (7):596-601, 2018. Five
groups of 5 mixed breed rabbits each were gavaged
5X109 CFU Salmonella typhimurium with or without 0.05ml/kg gentamicin (5mg/ml) and/or 40mg/kg
Ca-EDTA 40mg/kg, 24h post infection. Controls (n=5) were neither challenged nor
treated. Necropsies were performed at 48 and 96hrs after appearance of signs. At
necropsy, compared with controls, in those challenged with S. typhimurium
and/or treated, nodes appeared edematous, soft, hemorrhagic, and enlarged. In
rabbits challenged with S. typhimurium
only, there was severe lymphocyte depletion and necrosis. In those challenged
but given gentamicin only, or EDTA only, there was still lymphocytosis and
macrophage infiltration with defined zones of necrosis, Finally in rabbits
challenged with S typhimurium, but
given both Gentamycin and EDTA, lymph nodes appeared normal macroscopically and
microscopically. We find that a single dose of gentamycin with EDTA given 24h
after challenge, may prevent mesenteric lymph node pathology induced by S typhymurium in
rabbits
Key
words: Salmonella, rabbits, Mesenteric lymph nodes,
Ca-EDTA, gentamicin.
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