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OJVRTM
Online Journal of Veterinary Research©
Volume 25 (1): 70-78, 2021.
Effect of s-adenosyl
methionine on serum progesterone, estrogen and ovarian follicles
in albino rats exposed to carbon
tetrachloride.
Jalal A Al-Saedi1 and Jawad K Arrack2
1Al-Farahidi University Medical laboratories,
Baghdad, 2Department of Physiology and Pharmacology, College of Veterinary
Medicine, University of Baghdad, Iraq.
ABSTRACT
Al-Saedi JA, Arrack JK., Effect of s-adenosyl
methionine on serum progesterone, estrogen and ovarian follicles in albino rats
exposed to carbon tetrachloride, Onl J Vet Res., 25 (1): 70-78, 2021. We describe effect of a Schiff base derivative of methionine (s-adenosyl methione) on ovarian
function and structure in albino female rats exposed to carbon tetrachloride.
Groups of 10 rats each were injected intraperitoneally 48mg/kg s-adenosyl methionine, [0.1ml] 100mg/kg carbon tetrachloride
or both in 0.5mg/kg olive oil twice a week for six weeks. Controls
were injected 0.5ml DMSO. Blood was taken at days 0, 21 and 42. Compared with
controls, in rats given only methionine, serum progesterone increased ~30% at
day 21 and 42% by day 42 whereas in those injected carbon tetrachloride,
declined ~39 and 48% (P < 0.05). In rats given both, there were no
significant changes. Serum estrogen
increased ~20% by day 42 in rats given methionine but declined 41 and 51% by
day 42 in those given carbon tetrachloride. However, in rodents injected both
we found no significant variations. Microscopy revealed normal ovarian
structure and follicles in control rats given DMSO or methionine with increased
number of normal follicles. However, in those given only carbon tetrachloride we
found degeneration of mature follicles, extensive congestion and severely
degenerated trophoblastic cell. In rats given carbon tetrachloride together
with s-adenosyl we observed normal histology suggesting
that the latter may ameliorate toxicity induced by the toxin.
Keywords: Schiff
base, methionine, Carbone tetrachloride, Antioxidant.
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