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OJVRTM
Online
Journal of Veterinary Research ©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 28
(2): 98-114, 2024.
In silico methylene-tetrahydrofolate
reductase
Gobind Ram
Department of Biotechnology
& Bioinformatics, Lyallpur Khalsa College, jalandhar, Punjab, India.
ABSTRACT
Ram G., In silico methylene-tetrahydrofolate reductase, Onl J Vet Res., 28 (2): 98-114, 2024. Methylene-tetra-hydrofolate reductase (MTHFR) is encoded on chromosome 1
location p36.3. Methylation of
homocysteine to methionine is catalyzed by MTHFR through reduction of 5, 10-
methylene-tetrahydrofolate to 5-methyltetrahydrofolate. Approximately 24 mutations in the MTHFR gene
have been identified in persons with homocysteinuria.
C677T (rs1801133) and A1298C (rs1801131) single nucleotide polymorphisms with mutations
at C677T can substitute amino acid Ala222Val and A1298C, Glu429Ala. Polymorphism
and mild hyper-homocysteinemia are associated with
neural tube defects in offspring, arterial/venous thrombosis and cardiovascular
disease and MTHFR gene may be a risk factor for schizophrenia. In silico analysis was performed for homology
search, motif and domain prediction, interacting partners and model validation for
drug design. Lead molecule drug properties were checked by Mol
Inspiration and OSIRIS property explorer, docking with Vina
autodock and phylogenetic analysis of MTHFR with
Mega4 against 3 taxa.
Key words : Methylene-tetra-hydrofolate reductase, homocysteinuria, In Silico drug.
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