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OJVRTM
Online Journal of
Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 27 (4): 238-243, 2023.
Molecular docking substrate stabilization for Microsporum
canis keratinase
MVK Karthik,
Hanan Syed, Tridisha Goswami, Pratyoosh Shukla
Birla Institute of
Technology, Mesra, Jharkhand, India.
ABSTRACT
Karthik MVK, Syed H, Goswami T, Shukla P., Molecular docking substrate stabilization for Microsporum canis
keratinase, Onl J Vet Res., 27 (4): 238-243, 2023. Keratinophilic fungi degrade keratin. In
this study we modeled keratinase of Microsporum canis and confirmed its accurary with a RMS Z score (1.432) using PROVE software.
Molecular docking between modeled keratinases from species of keratinophilic fungi viz. Microsporum
canis with different types of keratins as
substrates was performed with scores of -451.89 kj/mol and -262.37 kj/mol, respectively. Arg1031
is conserved in keratinase while interacting with both keratins
Key
words: Keratinophilic fungi, keratin, keratinase,
Microsporum canis,
molecular docking.
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