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OJVRTM
Online Journal of
Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 26 (4): 302-305, 2022.
Effect of methanolic
extract of momordica dioica on phenytoin induced cognitive impairment
in albino mice.
Deshpande PS, Page AB.
School of
Pharmacy and Technology Management, SVKM’s, NMIMS, Shirpur,
India
ABSTRACT
Deshpande PS, Page AB, Effect of methanolic extract
of momordica dioica on phenytoin induced cognitive impairment
in albino mice, Onl J Vet Res., 26 (4): 302-305, 2022.
Four groups of five 20-30gm albino mice were gavaged
daily for 7 days with 25mg/kg phenytoin
(1), 500mg/kgf methanolic
extract of Momordica dioica (2),
both then followed by 25mg/kg phenytoin (3) or 12.5mg/kg phenytoin (4).
Controls were gavaged 10ml/kg vehicle. Cognition and
memory were tested by elevated plus maze, pole climb for avoidance, maximal
electroshock and passive avoidance. Compared with controls (P < 0.05) we
found extract per se reduced
convulsions 70% and given with phenytoin 55-68%. Time spent in open arm maze
increased 12% in mice gavaged phenytoin but declined
11% with extract and reduced time in open arms 53%, and both 35-75%. Entries
increased 55-63% with extract. Pole avoidance declined 79% in mice given
phenytoin but in those given extract we found no effect. Findings suggest extract inhibited effect of phenytoin on mice
cognition.
Key-words:
Cognition, mice, phenytoin, momordica dioica.