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OJVRTM
Online Journal of Veterinary Research©
Volume 20(5):335-344, 2016.
Effect of N-type calcium channel blocker Ziconotide
on memory in rats following morphine withdrawal.
Hooman Bozorgi DVM PhD1,
Ali Jahanian-Najafabadi Pharm D PhD2 and
Mohammad Rabbani MSc PhD*1.
1Department(s)
of Pharmacology and Toxicology, 2Biotechnology, Pharmaceutical Sciences Research Division, Isfahan
University of Medical Sciences, Isfahan, Iran.
1*Corresponding
author
ABSTRACT
Bozorgi H, Jahanian-Najafabadi
A, Rabbani M., Effect of N-type calcium channel blocker Ziconotide
on memory in rats following morphine withdrawal, Onl
J Vet Res., 20(5):335-344, 2016. Effect
of ω-Conotoxin MVIIA (Ziconotide or
SNX-111) neuron N-type calcium channel antagonist on withdrawal-induced memory
deficit in rats is described. Morphine dependent rats
were given ziconotide with daily doses of morphine or
administered singly.
Withdrawal was induced with 2mg/kg intraperitoneal (IP) naloxone. A single
intrathecal (IT) injection of ziconotide
(1µg/rat) led to an increase in the value of recognition index score from -7.28
± 1.33 % in morphine withdrawal animals to 7.84 ± 0.29 % (P
< 0.05).
In chronic administration, all 3 doses of ziconotide
significantly improved the withdrawal-caused memory deficits (P
< 0.05).
Improvement of memory function was not dose-dependent and optimized at 0.3 µg/rat. It
is concluded that ω-conotoxin in
both acute and chronic consumptions attenuated the intensity of memory loss
after morphine withdrawal.
KEY-WORDS: N-type calcium channel blocker, memory, naloxone-induced
morphine withdrawal, rat.
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