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OJVRTM
Online
Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 30 (8): 502-507, 2026.
Effect of nitroxynil and moxydectin on micronuclei in sheep
Adam ML,
Torres RA, Sponchiado G, Requião
L, Oms PA.
Laboratório
de Citogenética; Núcleo de Ciências Biológicas e da Saúde; Centro Universitário
Positivo, UnicenP. Laboratório de Genômica Evolutiva e Ambiental, Departamento
de Zoologia, UFPR. Centro Politécnico; Jardim das Américas; Curitiba, PR,
Brazil.
Adam ML, Torres RA, Sponchiado
G, Requião L, Oms PA., Effect of nitroxynil and moxydectin on
micronuclei in sheep,Onl J Vet Res., 30
(8) :502-507, 2026. Blood cell micronucleii are associated with structural and numerical
abnormalities in DNA. Micronuclei assays were used to determine the
genotoxicity of 1ml/50kg
nitroxynil at 45 days
age and 1ml/25kg at 105 days age in 2 groups of 5 Suffolk sheep. One thousand
cells were analyzed per sheep. Controls had a spontaneous basal rate of micronucleation (2.12 x 10-3), comparable with
background micronuclei frequencies shown to be around 2 x 10-3 in
other species and 0.69 x 10-3 in Ovis aires. There was no significant
difference between treated and control in frequency of micronucleated
cells.
KEY WORDS: micronucleus assays, genoxicity,
anthelmintics, sheep.