©1996-2018. All Rights Reserved. Online Journal
of Veterinary Research . You may not store these pages
in any form except for your own personal use. All other usage or distribution
is illegal under international copyright treaties. Permission
to use any of these pages in any other way besides the before mentioned must be
gained in writing from the publisher. This article is exclusively
copyrighted in its entirety to OJVR. This article may be copied once but may
not be, reproduced or re-transmitted without the express permission of the
editors. This journal satisfies the refereeing requirements (DEST) for the
Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this
page you must link directly to this page only here rather than put up your own
page.
OJVRTM
Online Journal of Veterinary Research©
Volume
18(5): 398-404, 2014. Redacted 2017.
Concurrent
adrenocortical adenoma and multicentric lymphoma in a
German shepherd dog.
Reza Kheirandish1, Baharak Akhtardanesh2, Nasrin
Askari1, Neda Ghasemi2
1Department(s)
of Pathobiology and 2Clinical
Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
ABSTRACT
Kheirandish R, Akhtardanesh B, Askari
N, Ghasemi N., Concurrent adrenocortical adenoma and multicentric lymphoma in a German shepherd dog. Onl J Vet Res., 18(5): 398-404, 2014.
A 6-year-old male German shepherd dog was referred with a history of polyuria, polydipsia, lethargy and
weight loss noted by the owner for 2 months previously. The dog exhibited
generalized lymphadenomegaly, hepatomegaly, abdominal
distention, and symmetrical alopecia with comedone
formation in the ventral abdomen. Blood tests revealed mild leukocytosis,
elevated aspartate aminotransferase, alanine aminotransferase, alkaline
phosphatase and hypercholesteremia. Hepatic and
spleen enlargement was confirmed by radiography. Abdominal ultrasonography
showed a mass on the left adrenal gland. A low dose dexamethasone suppression
test suggested a diagnosis of adrenal dependent Cushing disease. Medical
treatment was started with Mitotane but 5 days later euthanasia was selected by the owner due to the animal’s condition. At
necropsy, an irregular mass in the marginal left adrenal gland with enlargement
of superficial and mesenteric lymph nodes with metastatic foci in spleen and
liver were observed. Histopathological examination revealed lymphoid cells
containing large vesicular nuclei with increased mitotic figures. The adrenal
mass was composed of well-differentiated steroid
hormone producing cells. The abundant cytoplasmic area of tumor cells was
lightly eosinophilic and vacuolated. Tumor cells were arranged in broad
trabeculae by small vascular spaces and focal areas of calcification. A
definitive diagnosis of concurrent adrenocortical adenoma and multicentric lymphoma was made based on the clinical,
laboratory and pathological findings in this dog. To authors’ knowledge, this
is the first report of this association in dogs.
Key words: Adrenocortical Adenoma, Multicentric
Lymphoma, German Shepherd.
FULL-TEXT (SUBSCRIPTION OR PURCHASE TITLE $25USD)