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OJVRTM
Online Journal of
Veterinary Research©
Volume 18(6): 448-455, 2014. Redacted 2017.
Pulmonary myxoma with adenomatosis
(Jaagsiekte) in a fat tailed sheep
Reza Kheirandish1*, Shahrzad Azizi1, Masoud Sami2
1Department(s) of
Pathobiology and 2Food Hygiene and Public Health, Faculty of Veterinary
Medicine, Shahid Bahonar
University of Kerman, Iran
ABSTRACT
Kheirandish R, AziziS, Sami M.,
Pulmonary myxoma with adenomatosis
(Jaagsiekte) in a fat tailed sheep, Onl J Vet Res., 18(6): 448-455, 2014. Myxoma is a soft tissue tumor with primitive mesenchymal
cells and myxoid matrix rich in mucopolysaccharides.
In humans and domestic animals, myxoma occurs in
subcutaneous tissues and rarely in viscera. A concomitant occurrence of Jaagsiekte or ovine
pulmonary adenocarcinoma (OPA) with myxoma in a fat
tailed sheep at slaughter is reported. In domestic animals, the most common
primary tumor in the lungs is OPA, a contagious retrovirus-induced lung
neoplasm whereas primary tumors such as myxoma are
uncommon. In
this case, multiple, grayish-white, subpleural
nodules were distributed mainly on the dorsal surfaces of the cranioventral lobes. The nodules had a smooth surface, well demarcated
and rather firm in consistency. Histopathologic
examination revealed characteristics of two type neoplastic patterns including OPA and myxoma. In OPA, alveoli were lined by cuboidal to low columnar neoplastic
cells including pneumocytes type II and Clara cells that were
arranged in acinar
pattern to papillary projections. Immunolabelling for
Jaagsiekte sheep retrovirus capsid protein exhibited
positive reaction in the cytoplasm of the alveolar
type II epithelial cells, alveolar macrophages and lymphocytes of the
neoplastic regions. In the vicinity of OPA lesions, multi-encapsulated
foci of myxoma with low cellularity and abundant myxoid matrix were observed. These foci were
microscopically lobulated by thin fibrous septa and comprised of stellate,
elongated or ovoid cells with scant cytoplasm.
Key words: Myxoma, sheep, lung,
histopathology.
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