©1996-2011 All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in
any form except for your own personal use. All other usage or distribute on is
illegal under international copyright treaties. Permission to use any of these
pages in any other way besides the
before mentioned must be gained in writing from the
publisher. This article is exclusively copyrighted in its entirety to OJB
publications. This article may be copied once but may not be, reproduced or re-transmitted without the
express permission of the editors. This journal satisfies the refereeing requirements
(DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this
page you must link directly to this page only here rather than put up your own
page.
OJBTM
Online Journal of Bioinformatics ©
Volume
12(2):395-412, 2011
In Silico model of Homo sapiens Nectin-4: a novel anticancer drug
target
Dipon Das, Ranjan
Preet, Purusottam Mohapatra, Shakti Ranjan Satapathy, Chanakya Nath Kundu.
KIIT School of Biotechnology,
KIIT University, Campus-11, Patia, Bhubaneswar,
Orissa, India.
ABSTRACT
Das D, Preet
R, Mohapatra P, Satapathy
SR, Kundu CN. In Silico
model of Homo sapiens Nectin-4: a novel anticancer drug target, Online J
Bioinformatics, 12(2):395-412, 2011. Nectin 4 is a serum biomarker for
cancer as it is highly expressed in cancer cell lines and tumor tissues but not
in normal cells. In this study the Nectin-4 protein molecule of Homo sapiens was characterized in silico and its protein structure was predicted using commercial and available
online tools. A 3D structure of Nectin-4 was created by homology modeling. Stereochemistry
revealed that 99.5% of the residues of the model were in the most allowed
regions. Nectin-4 bound to adaptor protein Afadin.
Keywords: Active site prediction,
Adhesion molecule, Nectin-4.