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OJVRTM
Online Journal of Veterinary Research ©
Volume 14 (2):
254-258, 2010. Redacted 2017.
Olfactory
neuroblastoma in a horse.
Barbara Bacci (DVM, PhD, DECVP) Barbara Brunetti (DVM, PhD, DECVP), Federico Morandi
(DVM, PhD), Giuseppe Sarli (Prof, DVM),
Mario Pischedda (DVM)*, Cinzia Benazzi (Prof, DVM, DECVP)
Department of Veterinary Public Health and
Animal Pathology, Faculty of Veterinary Medicine, University of Bologna, Italy. * Veterinary practitioner, Bologna, Italy
ABSTRACT
Bacci B, Brunetti B, Morandi F, Sarli G, Pischedda M, Benazzi C., Olfactory neuroblastoma in a horse, Onl J Vet
Res, 14 (2): 254-258, 2010, Olfactory
neuroblastoma is an uncommon malignant neuroectodermal
nasal tumor thought to arise from the specialized sensory neuroepithelial
olfactory cells normally found in the upper part of the nasal cavity. This
report describes the histopathologic, immunohistochemical
and ultrastructural features of an olfactory neuroblastoma in a horse. A
25-year-old Argentine gelding horse was examined for progressive masticatory
and respiratory dysfunction. A mass
protruding from the right nasal cavity was found. Microscopically, the mass
showed infiltrative growth, and was composed of packed nests of polygonal to
round cells divided by a delicate fibrovascular
stroma. At immunohistochemistry, all neoplastic cells were strongly positive
for NSE and 80% of neoplastic cells were immunoreactive
for vimentin and chromogranin A. Synaptophysin, pankeratin, CD3, CD79, S-100 and GFAP were negative. At TEM cells had abundant to scant cytoplasm was clear
and contained dispersed mitochondria, some free ribosomes, and rare dense core
vesicles. Sustentacular-like cells were frequently
seen at the periphery of the cell nests. The
microscopic features of OBN may vary and the presence of rosettes and pseudorosettes cannot be considered a distinctive marker of
OBN. Therefore, diagnosis should be based on a combination of immunohistochemical and TEM examination.
Key Words: olfactory neuroblastoma, horse,
immunohistochemistry, electron microscopy
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