©1994-2018. All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under International copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editor
OJVR
Online Journal of Veterinary Research©
Volume 14 (2):116-120, 2010. Redacted
2017.
Haemagglutinating
pattern of some Nigerian isolates of Highly Pathogenic Avian Influenza H5N1 to
mammalian and avian erythrocytes
Ismaila Shittu (BSc., MSc.),
Clement A Meseko (DVM, MSc.), Lanre
K. Sulaiman (DVM, MVSc.), Kayode A. Olawuyi (BMLS), Ponman Solomon (DVM, MSc.), Agnes T. Oladokun
(DVM, MSc.), Davou C. Nyam
(OND, HND), Anthony N. Egbuji (DVM, MVSc.), Hussaini G. Ularamu (DVM, MSc.), Dorcas A. Gado
(BSc., AMLT),
Ijeoma O. Nwagbo (BSc., MSc.) and
Tony M. Joannis (DVM, MSc.)
Virology
Research Division, National Veterinary Research Institute, PMB 01 Vom, Plateau State, Nigeria.
ABSTRACT
Shittu I, Meseko
CA, Sulaiman LK, Olawuyi
KA, Solomon P, Oladokun AT, Nyam
DC, Egbuji AN, Ularamu HG, Gado DA, Nwagbo IO, Joannis TM., Haemagglutinating pattern of some Nigerian isolates of
Highly Pathogenic Avian Influenza H5N1 to mammalian and avian erythrocytes, Onl J Vet Res, 14
(2):116-120, 2010. The haemagglutination
binding pattern of Nigerian isolates of HPAI H5N1 to selected erythrocytes of
mammalian and avian origin was investigated. Fifteen isolates of the virus from
8 states in Nigeria were tested using rapid haemagglutination
(RHA) test against five mammalian and five avian erythrocytes. Erythrocytes of
human, dog, chicken, turkey, quail, geese and duck were agglutinated by all the
isolates while cow and horse erythrocytes were agglutinated by 14 of the
isolates. On the contrary, none of the isolates agglutinated pig erythrocytes.
Further investigation with erythrocytes from 4 different breeds of pigs showed
similar pattern of non-agglutination. This work shows that pig erythrocytes
hove poor or no affinity for Nigerian isolates of HPAI which may suggest low
expression or lack of receptors for HPAI in this species. Further work is
required to determine the molecular basis for this variation.
KEYWORDS:
HPAI, Haemagglutination, Erythrocytes, Nigeria
FULL-TEXT(SUBSCRIBERS
OR PURCHASE ARTICLE)