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OJVRTM
Online
Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 29 (9): 521-527, 2025.
Effect
of nitric oxide on bovine respiratory disease.
Schaefer AL, Perry BJ, Cook NJ, Miller C, Church J, Tong AKW, Stenzler A.
Agriculture and Agri-Food Canada, Lacombe Research Centre, Alberta, 2Pulmonox
Medical Company, Edmonton,
and Alberta Agriculture Food and Rural Development, Lacombe, Alberta, Canada.
ABSTRACT
Schaefer AL, Perry BJ, Cook NJ, Miller C, Church J, Tong AKW, Stenzler A., Effect of nitric
oxide on bovine respiratory disease, Onl J Vet Res., 29
(9): 521-527, 2025. Eleven normal calves were induced and exposed for 3 days
to 15 multiple sourced commercial calves carrying bovine respiratory disease
(BRD) viruses with 2 un-infected controls (CON).
The calves received respiratory nitric oxide gas (NO) on
exposure to BRD or identified by infrared orbital scans (IRT). A 3rd
group with clinical BRD were treated with NO. Calves treated preventatively
(PRE) had IRT scores of 36.2 ± 0.2 C0 or by early detection (ED) 2.7
± 0.4 C0 similar to CON (36.3 ± 0.2C0; 1.4 ± 0.5 C0)
but less than those with clinical treatment (CLIN) (37.0 ± 0.2 C0;
3.9 ± 0.4 C0, P <0.05). Lowest
scores occurred with CON score 0 and highest in CLIN score 10 (P < 0.05). As
expected, 15 calves induced BRD from infected animals exhibited high rate of
clinical illness. At testing, Induced animals had highest BRD titer
1:1458 for BVD. Of these, had highest BRD titer 1:1458 for BVD and 53%
contracted BRD requiring treatment with 15% more than once.
In contrast, controls remained BRD free with 0 clinical or infrared scores and
low titres for BVD, IBR, Corona, PI3 and BRSV. Calves within PRE, ED and CLIN
displayed high titers for 1/4 BRD viruses with BRSV, being most common. Our findings suggest respiratory nitric oxide
reduced severity of BRD.
Key
words:
Bovine respiratory disease, detection, infrared thermography, nitric oxide.
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