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OJVRTM
Online
Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN
1328-925X
Volume 28(4): 174-203, 2024.
GltC transcription binding
DNA motif co-regulated genes in nitrogen fixing bacteria.
Khan F, Agrawal S, Mishra BN.
Institute of Engineering
& Technology, India.
Khan F,
Agrawal S, Mishra BN., GltC transcription binding DNA motif co-regulated genes in
nitrogen fixing bacteria. Onl J Vet Res., 28 (4): 174-203,
2024. GltC
transcription factor regulating expression of glutamate synthase (GS) has been verified
in Bacillus subtilis, but it
also represses transcription of its own gene. Glutamate synthase induces metabolism
in nitrogen fixing bacteria. We report genome wide localization of GltC, binding and co-regulated genes. Upstream genomes of
bacteria revealed genes with GltC motifs, and at
lower thresholds, glutamate synthase GltC
co-regulated genes can be attained in nitrogen fixing bacteria. The bacterial
genomes also showed presence of GltC like proteins
categorized as transcription regulators of LysR
family. These predicted LysR proteins revealed
identification of characteristic LysR domains, which
were conserved with one another. The difference in binding motif patterns of GltC like motifs can be described to amino acid variation
of LysR domain of the GltC
like proteins who may cause expression of different set of proteins in
different bacteria. There is further scope to perform specific comparative
analysis of GltC binding motif elements in these
nitrogen-fixing bacteria in order to describe the nature of patterns of
expression of related co-regulated genes. Such computational studies are needed
to be verified through precise experimentations.
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