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OJVRTM
Online Journal of
Veterinary Research©
(Including Medical and
Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 27 (11): 651-658, 2023.
Pharmacodynamics of
intravenous paracetamol in buffalo calves.
Sushma Lalita Baxla, C Jayachandran, Birendra Kumar Roy, Ravuri Halley
Gora, M Kumar.
College of Veterinary Science & A. H., Ranchi,
Bihar Veterinary College Patna Jharkhand, India.
ABSTRACT
Baxla SL, Jayachandran C, Roy BK, Gora RH, Kumar M., Pharmacodynamics
of intravenous paracetamol in buffalo calves, Onl J
Vet Res., Volume 27 (11): 651-658, 2023. We report plasma and urine paracetamol levels after
single 40mg/kg intravenous injection in 5 buffalo calves. Paracetamol was determined by
spectrophotometry. Plasma levels were detected 4min to 2h whereas in urine up
to 48h. Plasma distribution rate constant (α) 7.148± 1.361h-1, half life (t1/2α) 0.11± 0.01h, urine elimination
(β) 0.965 ± 0.136h-1 and
half- life (t1/2β) 0.77± 0.09h suggested rapid distribution and elimination. Rapid loss suggested low retention of 1.00 ±
0.01h with area under curve 15.59± 1.07mg/L.h and
AUMC 16.09 ± 2.56 mg/L.h2, K12 1.672 ± 0.142 and K21 4.970 ± 1.540h-1. We found thorough
distribution of paracetamol due to high Vdarea (2.34 ± 0.19L/kg) and
tissue to plasma concentration ratio 0.59 ± 0.13.
Key words : Disposition kinetics; urinary
excretion, paracetamol, buffalo.
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