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OJBTM
Online Journal of Bioinformatics ©
Volume 13(3):375-381, 2012.
A Parkinson’s disease mitochondrial dysfunction pathway
with gene hubs.
Indumathi Kamatchi Balakrishnan
MSc Mphil, Saranya Rangasamy MSc, Mphil, Jeyakumar Natarajan PhD.
Department
of Bioinformatics, Bharathiar University, Coimbatore,
Tamilnadu, India.
ABSTRACT
Balakrishnan ik, Rangasamy
s, Natarajan j., A Parkinson’s disease mitochondrial
dysfunction pathway with gene hubs, Online J Bioinform.,
13(3):375-381, 2012. Mitochondrial
dysfunction in Parkinsons
disease leads to increased production of reactive oxygen species detrimental to
neurons. A mitochondrial dysfunction
pathway map was constructed from the literature and KEGG database. The resulting network was topologically analyzed for
target drug gene hubs. Results suggest
that OXIDATIVE STRESS (most
significant), DJ-1, ALPHA SYNUCLEIN
AGGREGATION, PI3 and KINASE/AKT
SIGNALLING hubs could have potential therapeutic use.
KEY-WORDS:
Parkinson’s disease, Oxidative stress, Mitochondrial
dysfunction, Topological analysis