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OJVRTM

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume  29 (12): 754-763, 2025.

Pasteurella multocida vaccine for hemorrhagic septicemia in cattle.

 

Khin MN, Zamri-Saad M, Noordin MM, Effendy AWM

 

1Faculty (s) of Veterinary Medicine, Universiti Putra, Universiti Malaysia Terengganu,  Malaysia.

 

ABSTRACT

 

Khin MN, Zamri-Saad M, Noordin MM, Effendy AWM., Pasteurella multocida vaccine for hemorrhagic septicemia in cattle. Onl J Vet Res., 29 (12): 754-763, 2025. We describe effect of vaccination with P. multocida B:2 on hemorrhagic septicemia in calves. Calves were given 5ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were mingled with the vaccinated cattle whereas untreated controls were kept separate. By 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At necropsy none of vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Exposed and commingled calves had  (p<0.05) higher levels of serum IgG. However, P. multocida B:2 could only be isolated from controls. Results suggest intranasal live attenuated P. multocida B:2 prevented infection. .

 

Keywords: Intranasal, attenuated Pasteurella multocida B:2, infection.

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