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OJVRTM

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 29 (5): 259-268, 2025.

Effects of lindane, clonazepam, ivermectin and permethrin on clonic seizures in mice.

 

 

Samini M, Shafarood H, Sehat V, Allahdini S.

 

Department of Pharmacology,  University of Medical Sciences, Tehran, Iran

 

ABSTRACT

 

Samini M, Shafarood H, Sehat V, Allahdini S., Effects of lindane, clonazepam, ivermectin and permethrin on clonic seizures in mice., Onl J Vet Res., 29 (5) : 259-268, 2025. We describe effects of lindane and permethrin on pentylene-tetrazole (PTZ) clonic seizure in mice. In controls. seizure threshold for PTZ was 35.290.56 mg/kg whereas in those given lindane decreased to 28.100.70 and with permethrin 22.900.80 mg/kg. Treatment with lindane or permethrin antagonized effects of clonazepam and ivermectin on PTZ-induced seizure threshold. The results suggest that increasing the PTZ-induced threshold with clonazepam and ivermectin may be due to a competition between these drugs as GABAA agonists and PTZ as GABAA antagonist. Decreasing the PTZ-induced threshold with lindane and permethrin may be due to additive antagonistic effect of PTZ and these agents on GABAA receptor. Decreasing the agonistic effects of clonazepam and ivermectin on PTZ-induced seizure with lindane and permethrin may show a competition between these agonists and antagonists on GABAA receptor. Lindane also was more powerful convulsant than permethrin.

 

KEY-WORDS: Lindane, Permethrin, Ivermectin, Clonazepam, PTZ, Clonic seizure.

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