©1994-2018.
All Rights Reserved. Online Journal of Veterinary Research.
You may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJVR publications. This
article may be copied once but may not be, reproduced or re-transmitted without
the express permission of the editors.
OJVRTM
Online Journal of
Veterinary Research©
Volume 9 (1) : 38-46, 2005,
redacted 2018.
Effects
of lindane and permethrin on pentylenetetrazole-induced
clonic seizure in mice
Samini M*, Shafarood H, Sehat V, Allahdini S.
Department of
Pharmacology, School of Medicine, Tehran University of Medical Sciences,
Tehran, Iran
ABSTRACT
Samini M, Shafarood
H, Sehat V, Allahdini S.,
Effects of lindane and permethrin on pentylenetetrazole-induced clonic
seizure in mice, Onl J Vet Res 9 (1) : 38-46, 2005. We
report effects of lindane and permethrin, antagonists of the GABAA
receptor/chloride channel complex, on pentylenetetrazole-induced
clonic seizure threshold in mice. In controls,
seizure threshold of pentylenetetrazole (PTZ) was
35.29
0.56 mg/kg. In
pre-treated mice with clonazepam or ivermectin,
agonists of GABAA receptor/chloride channel complex, a dose-dependent increase in the amount
of PTZ was required to induce seizure. In
animals pretreated with lindane or permethrin, PTZ-induced
seizure threshold decreased to 28.100.70 and 22.900.80 mg/kg, respectively.
Pretreatment of mice with lindane or permethrin
antagonized the effects of clonazepam and ivermectin
on PTZ-induced seizure threshold. The results suggest that increasing
PTZ-induced threshold with clonazepam and ivermectin
may be due to a competition between these drugs as GABAA
agonists and PTZ as GABAA antagonist. Decreasing the PTZ-induced threshold with
lindane and permethrin may be due to additive
antagonistic effect of PTZ and these agents on GABAA receptor.
Decreasing the agonistic effects of clonazepam and ivermectin
on PTZ-induced seizure with lindane and permethrin
may show a competition between these agonists and antagonists on GABAA
receptor. Lindane
also was more powerful convulsant than permethrin.
KEYWORDS: Lindane, Permethrin, Ivermectin,
Clonazepam, PTZ, Clonic seizure