________________________________________1994-2019. All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyr

1994-2019. All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors.

OJVRTM

Online Journal of Veterinary Research©

Established 1994
ISSN 1328-925X

Volume 22 (9):793-798, 2018.

Effect of branched chain amino acid supplement on hydrogen peroxide kidney and liver toxicity in Albino rabbits.

Fahad Saber Owain, Ahmed T Taha, Yaser AM Sulaiman.

Department of Animal production, College of Agriculture, University of Tikrit.

ABSTRACT

Owain FS, Taha AT, Sulaiman Y., Effect of branched chain amino acid and leucine supplement on liver and kidney hydrogen peroxide toxicity in albino rabbits, Onl J Vet Res., 22 (9):793-798, 2018. For two months, groups of 6 albino 4 to 5 month old rabbits each, were given water with 0.02% hydrogen peroxide (H₂O₂) and standard feed with 0.05, 0.1 or 0.2% branched chain amino acid (BCAA) mix, and 0.1% leucine. Controls were 6 rabbits each given water with or without 0.02% H₂O₂ and standard diet. After fasting 12h, blood was taken at days 30 and 60 for serum enzymes. Compared with normal controls, serum alanine and aspartame transaminases, urea and creatinine increased (P < 0.05) in peroxide controls. There were 3 fold increases in creatinine suggesting kidney or protein toxicity. The serum values also increased in rabbits supplemented BCAA but less so (P < 0.05) than peroxide controls especially by Day 60. At day 60 ALT values in peroxide rabbits given BCAA were normal. Our results suggest that BCAA supplements at higher doses may reduce hydrogen peroxide induced liver an/or kidney toxicity in rabbits.

Key words: Amino acid, supplement, hydrogen peroxide, liver kidney enzymes, creatinine, urea, rabbit. Raw Data provided.

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