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OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established
1994
ISSN
1328-925X
Volume 29 (5): 314-319,
2025.
Feline cholangio-hepatitis
steroid therapy.
Reche A, Chalita MC, Taranti L, Prosser CS
Faculty
of Veterinary Medicine, University of São Paulo, Brazil.
ABSTRACT
Reche A, Chalita MCC, Taranti L, Prosser CS., Feline cholangio-hepatitis steroid therapy, Onl J Vet Res., 29 (5): 314-319, 2025. We report effect of prednisone on clinical
and hepatic enzymes in 6 cats lymphocytic-plasmacytic cholangiohepatitis
(LCH). Of 38 liver biopsies 18 had lipidosis, 12 LCH,
4 lymphoma, 2 Platynosomiasis and 1 with bile duct
carcinoma so that only 6 cats with LCH were studied. Cats were given 2mg/kg
prednisone daily 30 days reduced 25% weekly then maintained 0.5mg/kg in
alternate days by 6th and 8th weeks and evaluated 30, 60,
90 and 180 days for serum alanine (ALT) and aspartate aminotransferases (AST),
alkaline phosphatase (ALP), gamma-glutamyltransferase
(CGT), bilirubin (TB), total protein
(TP) and albumin (ALB). Liver biopsies were excised by laparotomy for
microscopy. Compared with controls, in cats given prednisone ALT declined (P
< 0.05) ~81-90, AST 78-90, ALP ~73-99, CGT 45-55 and TB 96-98%. There was no
effect on serum proteins. Results suggest prednisone may have improved liver
function ~10%.
Key words:
lymphocytic-plasmacytic cholangiohepatitis,
prednisone, feline.
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