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OJVRTM
Online Journal
of Veterinary Research©
(Including
Medical and Laboratory Research)
Established
1994
ISSN
1328-925X
Volume 27 (12):679-686, 2023.
Effect of pumpkin seed (Cucurbita pepo L.) oil extract on 5, 10 and 15 day wound healing in Albino rats.
Shatha Mousa Mlaghee Al-Safi1,
Noor alhuda K Al-Murshedy1,2, Saadia Salleh Mehdy
Zieny1,2,
Nadia KJ Al-Dawah1,2,
Israa Saadi Abdulameer1,2, Lubna Majid Mohammed1,2
1Department(s) Of
Physiology and Pharmacology, 2Poultry, University of Al-Kufa, College of Veterinary Medicine, Najaf, Iraq.
ABSTRACT
Al-Safi SM, Al-Murshedy NAK, Mehdy Zieny SS, Al-Dawah NK, Abdulameer IS, Mohammed LM., Effect of pumpkin seed
(Cucurbita pepo L.) oil extract on 5, 10 and 15 day wound healing in Albino
rats, On J Vet Res., 27 (12):679-686, 2023. We report effect of pumpkin seed (Cucurbita pepo L.) oil extract of wound healing in 3 groups of 6
Albino rats each treated 5, 10 and 15 days. Under anaesthesia, one control saline
and treatment wound were induced dorsally by scalpel 15 and metzenbaum
scissors on each animal. Two 10X10mm circular full-thickness skin defect wounds
(10×10 mm) were made dorsally to border of panniculus
carnosus. Rats
were given 1ml/mg curcubita or saline (controls)
topically for 5, 10 and 15 days. Skin thickness was assessed by Vernier
calipers daily. For microscopy, skin samples were excised at necropsy by 5, 10
and 15 days treatment. Results suggest that compared with saline controls, rats
given curcubita 10-15 days had ~40% (P < 0.05)
less swelling. Compared with saline control skin, by microscopy, we observed re-epithelisation in rats given curcubita by 10 to 15 days.
Results suggest oil pumpkin seeds may affect wound healing in albino rats.
Keywords:
Pumpkin seed oil, Wound healing, Rats.
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