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OJVRTM

Online Journal of Veterinary Research©

Volume 21(9):543-548, 2017.

 Effect of Punica granatum on wound healing in male Sprague Dawley rats.

 

Elahe Faramarzi1, Samaneh Goorani2, Mohammad Mahdi Zangeneh3*, Akram Zangeneh4, Amir Amiri-Paryan4,

Maryam Almasi4, Fariba Najafi5, Reza Tahvilian6

 

 Kermanshah University of Medical Sciences, Kermanshah, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.

 

ABSTRACT

 

Faramarzi E, Goorani S, Mahdi Zangeneh M, Zangeneh A, Amiri-Paryan A, Almasi M, Najafi F, Tahvilian R., Effect of Punica granatum on wound healing in male Sprague Dawley rats, Onl J Vet Res 21(9):543-548, 2017. Effect of aqueous crude extract of pomegranate (Punica granatum) peel (PGP) on cutaneous wound healing in male Sprague-Dawley rats is reported. Full-thickness 2X2cm excisional dermal wounds were created on the back of 24 anaesthetized male rats. Groups of 6 each were then treated with 1ml basal Eucerin cream, Eucerin with 1ml tetracycline (3%), or 1ml 10% PGP aqueous crude extract in Eucerin daily, for 20 days. Controls (n=6) were wounded but not treated. Rats were euthanized at 20 days for gross and histopathological analyses. Results suggest that wound area was reduced, re-epithelization increased, total white cells, lymphocytes and macrophages reduced, but fibroblasts and fibrocytes increased, in rats treated with PGP, compared (P<0.05) with controls or other treatments.

 

Keywords: Punica granatum peel; wound healing, rats.

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