©1996-2014 All Rights
Reserved. Online Journal of
Veterinary Research . You may not store these pages in
any form except for your own personal use. All other usage or distribution is
illegal under international copyright treaties. Permission to
use any of these pages in any other way besides the before mentioned must be
gained in writing from the publisher. This article is exclusively
copyrighted in its entirety to OJVR. This article may be copied once but may
not be, reproduced or re-transmitted without the express permission of the
editors. This journal satisfies the refereeing requirements (DEST) for the
Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this
page you must link directly to this page only here rather than put up your own
page.
OJVRTM
Online Journal of Veterinary Research©
Volume 18(8):
623-630, 2014.
Atherosclerosis and cartilage metaplasia in a hypercholesterolemic rabbit
Miraghaii S¹, Siavosh Haghighi ZM DVM PhD²,
Bahrami G¹.
¹Medical Biology Research Center, Kermanshah
University of Medical Sciences, ²Department of Pathology , Faculty of
Veterinary Medicine, Razi University of Kermanshah,
Iran
ABSTRACT
Miraghaii
S, Zaghighi
SZM, Bahrami G., Atherosclerosis and cartilage
metaplasia in a hypercholesterolemic rabbit, Onl J Vet Res., 18(8): 623-630, 2014. Plasma cholesterol, plasma lipid levels and
vascular histopathology in a hypercholestrolemic
rabbit are described. Dietary
manipulation in rabbits can cause hypercholesterolemia which leads to
atherosclerosis (3,10). A male
white New Zealand rabbit weighing was fed 2% extra cholesterol per day for 8 weeks. At
day 8, serum cholesterol was 1741, TG 162, LDL 1547, HDL 363 and calcium 13
mg/dl. At necropsy no abnormality was visible except that the liver was
slightly enlarged and pale with rounded borders and thoracic aorta showed
slightly raised plaques along mural wall. Histopathology showed chronic severe
aortic lesions with atherosclerosis, hyaline cartilage metaplasia and
calcification. The findings suggested that the lesions were due to hypercholesterolemia which in previous studies have been
limited to intimal plaque formation without signs of chondrogenic
metaplasia.
Key words: Hypercholestrolemic rabbit, Atherosclerosis, Cartilage
Metaplasia.
FULL-TEXT (SUBSCRIPTION
OR PURCHASE TITLE $25USD)