©2021-2032 All Rights Reserved. Online Journal
of Veterinary Research. You may not store these pages in any form except for
your own personal use. All other usage or distribution is illegal under
International copyright treaties. Permission to use any of these pages in any
other way besides the before mentioned must be gained in writing from the
publisher. This article is exclusively copyrighted in its entirety to OJVR
publications. This article may be copied once but may not be, reproduced or
re-transmitted without the express permission of the editor.
OJVRTM
Online
Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 25 (9):606-614, 2021.. .
Effect of Astragalus polysaccharide on erythrocyte-complement
receptor type I adherence
in chickens
inoculated with infectious bursal disease virus.
Li Hongquan
College
of Veterinary Medicine and Animal Science, Shanxi Agricultural University, Taigu, Shanxi 030801,PRC, China.
ABSTRACT
Hongquan L., Effect of Astragalus
polysaccharide on erythrocyte-complement receptor type I adherence in chickens
inoculated with infectious bursal disease virus, Onl
J Vet Res., 25 (9):606-612, 2021. Four groups of 10
one day old leghorn SPF chicks blood samples were tested for IBDV then
inoculated 0.3ml infectious bursal disease virus (IBVD) (1) with or without 5
(2) or 10mg/kg (3) intramuscular Astragalus (APS). Controls were not treated (4). Cardiac blood was taken at 25-35 days for erythrocyte complement receptor type one (E-CR1)
activity determined by erythrocyte-C3b receptor (E-C3b RR) and immune complex
rosette rates (E-ICRR). In birds with IBVD not given APS incidence was
100% and mortality 24% whereas with 5mg Astralagus these values were ~55%, ~10% and 10mg/kg 43 and
7%, respectively. Compared with controls, E-C3bRR with IBVD but
without APS was ~34-54% lower (P < 0.01) but given
APS were not different. In chicks given 5mg/kg APS, E-C3bRR levels were lower
than chicks not given APS (p<0.05) and with 10mg/kg E-C3bRR recovered more
rapidly. Results suggest that APS may have prevented changes due to IBDV in erythrocyte-C3b receptor and immune
complex rosette rates and reduced morbidity and mortality.
Key words: Astragalus polysaccharides; Chicken; IBDV; Erythrocyte;
immune adherence.
FULL-TEXT (SUBSCRIPTION or PURCHASE TITLE)