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OJVRTM
Online Journal
of Veterinary Research©
Volume 26 (4): 306-312, 2022.
Abdul Salam Khoso1, Ahmed Nawaz Tunio1, Dildar Hussain Kalhoro2, Habibullah
Janyaro3, Atique Ahmed Behan*4,
Majeed Hakeem Dhamrah4,
Qurat Ul Ain5, Muhammad
Ali Chandio6
1Department of Veterinary
Surgery and Obstetrics, 2Department of
Veterinary Microbiology, 3Department of
Livestock Management, Faculty of Animal Husbandry and Veterinary Sciences Sindh
Agriculture University Tandojam, Pakistan, 5Department
of Anatomy, Peoples University of Medical and Health Sciences for Women, Nawabshah, 6Department of Veterinary Pathology, Shaheed Benazir
Bhutto University of Veterinary and Animal Sciences, Sakrand,
Pakistan.
*Correspondence: Email:
atiquebehan@sau.edu.pk
Cell #. +923003022105
ABSTRACT
Khoso AS, Tunio AN, Kalhoro DH, Janyaro H, Behan AA, Dhamrah MH, Ul Ain Q, Chandio MA., Oxidized
regenerated cellulose and gelatin sponge hemostat for liver injury in rabbit model,
Onl J Vet Res., 26 (4): 306-312, 2022. We report effect of oxidized regenerated cellulose (ORC)
and gelatin sponge (GS) on bleeding, healing and liver function in New Zealand
rabbits (Oryctolagus cuniculus). Two groups of 12 rabbits each were first
subjected to a 1 cm incision liver wound and then inserted ORC and GS on right
lobe. The animals were sacrificed at 12th and 18th day
post-surgery when hemostatic score and clotting time were recorded. Hemostatic
score at day 12 were 2.75±0.25 with GS and 2.51±0.65 with ORC and by day 18,
2.25±0.25 and 2.5±0.28 respectively. With GS or ORC clotting times were reduced
~28% by days 12 or 18 but serum bilirubin was 53-61% higher in rabbits given
ORC. We found no effect on alkaline phosphatases. Glutamic pyruvic transaminase
was 34-36% higher in animals given GS. Microscopy suggested that GS and ORC had
been fully absorbed at necropsy but ORC induced faster healing. Findings suggest
that GS was more efficient as hemostat but ORC induced faster healing.
Keywords: Liver
injury, Hemostatic agent, Gelatin
sponge, Oxidized regenerated cellulose, Rabbit. Raw
data provided.
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