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OJVRTM
Online Journal of Veterinary
Research©
Volume 21(8):475-483, 2017.
Effect of platelet rich plasma on guinea pig knee
joint osteoarthritis model.
Niloofar Seydi1, Seifollah N Dehghani.
Department of Surgery, School of Veterinary Medicine, Shiraz University,
1Present address: Department of Surgery, College of Veterinary
Medicine, Kermanshah University, Kermanshah, Iran.
ABSTRACT
Niloofar Seydi1, Seifollah N Dehghani.
Effect of platelet rich plasma on guinea pig knee joint osteoarthritis, Onl J Vet Res., 21(8):475-483, 2017. Osteoarthritis (OA) is the most common type of
arthritis and cause of chronic musculoskeletal disability in elderly people.
Platelet rich plasma (PRP) mimics the last step of the coagulation cascade,
leading to formation of a fibrin clot, which consolidates and adheres to the
application site. Under anesthesia, the anterior cruciate ligament of the left
knee of adult guinea pigs was transected. Guinea pigs were then allowed to resumed normal cage activity for 12 weeks. For PRP, 2ml
blood was collected into a Na-citrate tube by direct heart puncture. At 12
weeks, the PRP was injected into the OA joint in 10 guinea pigs and observed
for a further 8 weeks. Controls were not given PRP. Cranio-caudal
and lateral radiographs of the stifle joint were done at 12 and 20 weeks.
Radiological OA was assessed 0 to 5 depending on severity and histopathological
OA graded 1 to 3 by surface, matrix, cell distribution, cell
population viability, subchondral bone and mineralization. By 20 weeks, radiologic
and pathologic assessment confirmed development of OA in guinea pig controls,
whereas in those given PRP, there was a reduction in osteophyte formation and
subchondral bone sclerosis.
Key Words:Ostearthris, Plasma rich
plasma, Guinea pig.
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