1994-2019.
All Rights Reserved. Online Journal of Veterinary
Research. You may not store these pages in any form except for your
own personal use. All other usage or distribution is illegal under
international copyright treaties. Permission to use any
of these pages in any other way besides the before mentioned must be gained in
writing from the publisher. This article is exclusively copyrighted
in its entirety to OJVR publications. This article may be copied once but may
not be, reproduced or re-transmitted without the express permission of the
editors.
OJVRTM
Online Journal of Veterinary Research©
Volume 22 (8):659-668, 2018.
Effect of Rosa damascene gel
on cutaneous wound healing and tension forces in Sprague Daley rats.
Nasser Vajdi, Aboutorab Tabatabaei-Naeini, Alireza Raayat
Jahromi
Department of Clinical
Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
ABSTRACT
Vajdi N, Tabatabaei-Naeini A, Jahromi AR., Effect of Rosa
damascene gel on cutaneous wound healing and tension forces in Sprague Daley rats.
Onl J Vet Res., 22 (8):659-668, 2018. Rosa
damascene mill has been shown to have beneficial roles on wound healing but its effect
is not yet clear. We describe effects of Rosa damascene mill extract
gel on experimental cutaneous wound healing
and tension forces in male rats. Under anesthesia, groups of 10 Sprague Daley a circular 1cm diameter skin area between the 1st thoracic
vertebra 1cm proximal to the 1st lumbar was excised. The wound areas
were then treated with topical 5% or 10% rose base gel spray daily for 7 days. Controls were treated
with 0.2 % oxytetracycline spray or
base gel sprays. Samples were excised for microscopy
and tension force tests 10 and 21 days after surgery. By 21 days, compared
with controls and 5% rose gel, we found that 10% rose gel improved re-epithelialization
of stratum basalis, mature granulation tissue, hair follicles and sweat gland and
tension forces compared with other groups. We found least fibroblasts but most
vascularization at day 21 (P < 0.05) and lymphocytes highest (P < 0.05) at
10 days in rats sprayed 10% rosa
gel. Tension force data (P < 0.05 ) supported
subjective microscopy findings for rats treated with 10% rosa
gel.
Keywords Rosa damascene mill, wound healing, rat. Raw
data provided.
FULL-TEXT (SUBSCRIBE OR
PURCHASE TITLE $25USD)