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OJVRTM
Online Journal of Veterinary Research©
Volume 13 (1):26-31, 2009. Editors
note: Extensively redacted 2017.
LD50
of salinomycin in laying and broiler chickens with or
without oral phenobarbital and chloramphenicol
Rajaian Ha, Nazifi Sb* , Aberumandi Ma, Jalaei
Ja
aDepartments of Pharmacology and bClinical
Pathology, School of Veterinary Medicine, Shiraz University, Shiraz 71345-1731,
Iran
ABSTRACT
Rajaian
H, Nazifi
S , Aberumandi
M, Jalaei
J, LD50 of salinomycin in laying and
broiler chickens with or without oral phenobarbital and chloramphenicol, Online
J Vet Res, 13 (1) :26-31,
2009. The LD50 of salinomycin with or without oral phenobarbital and
chloramphenicol was determined in laying and broiler hens. The LD50 of salinomycin in broiler
chickens and laying hens was 108 and 104 mg/kg body weight, respectively.
Mortality decreased about 9% in layers given chloramphenicol or phenobarbital,
15% in broilers given chloramphenicol but 32% in broiler hens given
phenobarbital. There were no significant changes in biochemical parameters due
to salinomycin in any group. The LD50 of salinomycin in this study was similar to those reported
previously. Lower mortality due to
phenobarbital in broiler chickens given an LD50 dose of salinomycin may have been due to induction by phenobarbital
on liver microsomal enzymes.
Key
words: Salinomycin, LD50, Chickens, Chloramphenicol, Phenobarbital